Dr. Rajesh Manda
ABOUT ME
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collaboration: Interested in writing Research and Review articles in Synthetic Methodology, Heterocyclic Chemistry, C-H Functionalization, Alkyne Chemistry and Medicinal Chemistry (Please contact)
ORCID: 0000-0001-8106-6527
Google Scholar
Scopus
EDUCATION
CSIR-Indian Institute of Chemical Technology, Hyderabad, India
CSIR-Central Drug Research Institute, Lucknow, India
Ph.D. in Chemistry (Dec 2014–Dec 2020)
Advisor: Dr. Maddi Sridhar Reddy
Osmania University, Hyderabad
M. Sc. in Chemistry (2009–2011)
Kakatiya University, Warangal
B. Sc. in Chemistry (2006–2009)
EXPERIENCE
University of Nebraska Medical Center, Omaha, USA
Postdoctoral Research Associate (Jan 2024–Present)
Advisor: Prof. Amar Natarajan
Purdue University, West Lafayette, USA
Postdoctoral Research Associate (July 2021–Jan 2024)
Advisor: Prof. Arun K Ghosh
CSIR-Indian Institute of Chemical Technology, Hyderabad, India
Project Researcher (JCF) (Dec, 2020–July 2021)
Advisors: Dr. Saibal Das
INDUSTRIAL EXPERIENCE
Panacea Biotec LTD, Mohali, India
Chemistry Executive (2012-2014)
BIOSKETCH
I am currently working as a Postdoctoral Research Associate in the Department of Pharmaceutical Sciences
at the University of Nebraska Medical Center (UNMC), Omaha. My research is mainly focused on the synthesis of Regulated induced proximity targeting chimeras (RIPTACs) and Proteolysis Targeting Chimeras (PROTACs). I also worked as a PDRA in the Department of Chemistry at Purdue University, West Lafayette, USA. My research at Purdue focused on the synthesis of selective G Protein Coupled Receptor (GPCR) kinase inhibitors and Natural Product Synthesis. Despite of current work, I have a broad background in synthetic organic chemistry and medicinal chemistry with specific training and expertise in the synthesis of small to complex molecular architectures in short path. As a Project Researcher, I have developed the new synthetic route for chiral nicotine's synthesis cost-effectively in a multi-gram scale. During my Ph.D., I successfully disclosed the novel reactivities of alkynes for the synthesis of medicinally impartment functionalized heterocyclic complexes and produced multiple publications along with various fascaplysin derivatives and other industrial collaborated projects. In addition, I successfully administered the projects (e.g., research protections, budget and project supervision), collaborated with other researchers and produced several peer-reviewed publications from each project. As a result of these previous experiences, I am aware of the importance of frequent communication among project members and constructing a realistic research plan, and timeline. In summary, I have the expertise, leadership, training and motivation necessary to complete the proposed research project. Outside of the lab, I enjoy watching movies, cooking food, drinking good beer, and spending time with family.
collaboration: Interested in writing Research and Review articles in Synthetic Methodology, Heterocyclic Chemistry, C-H Functionalization, Alkyne Chemistry and Medicinal Chemistry (Please contact)
ORCID: 0000-0001-8106-6527
Google Scholar
Scopus
EDUCATION
CSIR-Indian Institute of Chemical Technology, Hyderabad, India
CSIR-Central Drug Research Institute, Lucknow, India
Ph.D. in Chemistry (Dec 2014–Dec 2020)
Advisor: Dr. Maddi Sridhar Reddy
Osmania University, Hyderabad
M. Sc. in Chemistry (2009–2011)
Kakatiya University, Warangal
B. Sc. in Chemistry (2006–2009)
EXPERIENCE
University of Nebraska Medical Center, Omaha, USA
Postdoctoral Research Associate (Jan 2024–Present)
Advisor: Prof. Amar Natarajan
Purdue University, West Lafayette, USA
Postdoctoral Research Associate (July 2021–Jan 2024)
Advisor: Prof. Arun K Ghosh
CSIR-Indian Institute of Chemical Technology, Hyderabad, India
Project Researcher (JCF) (Dec, 2020–July 2021)
Advisors: Dr. Saibal Das
INDUSTRIAL EXPERIENCE
Panacea Biotec LTD, Mohali, India
Chemistry Executive (2012-2014)
BIOSKETCH
I am currently working as a Postdoctoral Research Associate in the Department of Pharmaceutical Sciences
at the University of Nebraska Medical Center (UNMC), Omaha. My research is mainly focused on the synthesis of Regulated induced proximity targeting chimeras (RIPTACs) and Proteolysis Targeting Chimeras (PROTACs). I also worked as a PDRA in the Department of Chemistry at Purdue University, West Lafayette, USA. My research at Purdue focused on the synthesis of selective G Protein Coupled Receptor (GPCR) kinase inhibitors and Natural Product Synthesis. Despite of current work, I have a broad background in synthetic organic chemistry and medicinal chemistry with specific training and expertise in the synthesis of small to complex molecular architectures in short path. As a Project Researcher, I have developed the new synthetic route for chiral nicotine's synthesis cost-effectively in a multi-gram scale. During my Ph.D., I successfully disclosed the novel reactivities of alkynes for the synthesis of medicinally impartment functionalized heterocyclic complexes and produced multiple publications along with various fascaplysin derivatives and other industrial collaborated projects. In addition, I successfully administered the projects (e.g., research protections, budget and project supervision), collaborated with other researchers and produced several peer-reviewed publications from each project. As a result of these previous experiences, I am aware of the importance of frequent communication among project members and constructing a realistic research plan, and timeline. In summary, I have the expertise, leadership, training and motivation necessary to complete the proposed research project. Outside of the lab, I enjoy watching movies, cooking food, drinking good beer, and spending time with family.
Publications
18. Recent Progress in Arylmetalative Cyclization/Annulation of Functionalized Alkynes with Organoboranes. Manda Rajesh*and Gadi Ranjith Kumar* Asian J. Org. Chem. 2023, e202300106 (Review article)
16. Synthesis of bridgehead-azacycles via dual C–N/C–C annulation of α-amino acids, aminals and maleimides Nagender Thadem, Manda Rajesh, Harikrishna Balaboina and Saibal Das* Org. Biomol. Chem., 2022, 20, 6368–6383
15. Activator free diastereoselective 1,3-dipolar cycloaddition: a quick access to coumarin based spiro multi heterocyclic adducts Nagender Thadem, Manda Rajesh and Saibal Das* RSC Adv., 2021, 11, 29934-29938
14. Propargylic Alcohols as Coupling Partners in Transition-Metal-Catalyzed Arene C−H Activation Gadi Ranjith Kumar, Manda Rajesh, Shuimu Lin*, Shouping Liu* Adv. Synth. Catal., 2020. 362, 5238-5256 (VIP Review article, Interanational collaboration)
13. A Sequential Activation of Alkyne and C–H Bonds for the Tandem Cyclization and Annulation of Alkynols and Maleimides through Cooperative Sc(III) and Cp*-Free Co(II) Catalysis Ravi Kumar Gurram, ‡ Manda Rajesh, ‡ Maneesh Kumar Reddy Singam, Jagadeesh Babu Nanubolu, and Maddi Sridhar Reddy* (‡ equal contribution) Org. Lett. 2020, 22, 14, 5326–5330
12. Lewis-Acid-Catalyzed Decarboxylative Annulation of 2-Aminoindole-3-Carboxylate with Ynals Involving [3 + 2] Spirocycloaddition and 2,3-Aza Migration Manda Rajesh, Ravi Kumar, Surendra Puri, Jagadeesh Babu Nanubolu and Maddi Sridhar Reddy* Org. Lett. 2020, 22, 3, 1117–1123
11. Ni-Catalyzed electrophile driven regioselective arylative cyclization of ortho-functional diaryl acetylenes for the synthesis of pyridine and indene derivatives Maneesh Kumar Reddy Singam, Attunuri Nagireddy, Manda Rajesh, Veeramalla Ganesh and Maddi Sridhar Reddy* Org. Chem. Front., 2020, 7, 30-34
10. Base Mediated Tandem Vinylogous Addition and Cyclization of γ-Phosphonyl/Sulfonyl Crotonates and Ynones: Synthesis of Functionalized 2-Pyrones Matam Parameshwar, Manda Rajesh, Sridhar Balasubramanian and Maddi Sridhar Reddy* ACS Omega 2019, 4, 20, 18846–18854
9. Rh(III)-Catalyzed Intramolecular Oxidative Annulation of Propargyl Amino Phenyl Benzamides to Access Pyrido/ Isoquinolino Quinoxalinones Gurram Ravi Kumar, Ravi Kumar, Manda Rajesh, B. Sridhar,Maddi Sridhar Reddy* Adv. Synth. Catal., 2019, 361, 4825-4830
8. Mycobacterial protein tyrosine kinase, PtkA phosphorylates PtpA at tyrosine residues and the mechanism is stalled by the novel series of inhibitors Swati Jaiswal, Aditi Chatterjee, Sapna Pandey, Kiran Lata, Ranjith Kumar Gadi, Rajesh Manda, Sanjay Kumar, Maddi Sridhar Reddy, Ravishankar Ramachandran & Kishore K. Srivastava* Journal of Drug Targeting, 2019, 27:1, 51-59
7. 3-Heterosubstituted Benzofurans from Hydroxyphenyl Propargyl Alcohols via ortho-Quinone Methide through a Metal-/Catalyst-Free Conjugate Addition/Oxy-Cyclization Manda Rajesh, Maneesh Kumar Reddy Singam, Ranjith Kumar Gadi and Maddi Sridhar Reddy* ACS Omega 2018, 3, 12, 17155–17163
6. Nickel Catalyzed syn-Selective Aryl Nickelation and Cyclization of Aldehyde/Enone-Tethered Terminal Alkynes with Arylboronic Acids Manda Rajesh, Maneesh Kumar Reddy Singam, Surendra Puri, Sridhar Balasubramanian and Maddi Sridhar Reddy* J. Org. Chem. 2018, 83, 24, 15361–15371
5. A nickel-catalyzed anti-carbometallative cyclization of alkyne–azides with organoboronic acids: synthesis of 2,3-diarylquinolines Gadi Ranjith Kumar, Ravi Kumar, Manda Rajesh and Maddi Sridhar Reddy* Chem. Commun., 2018, 54, 759-762
4. A stereoselective thiocyanate conjugate addition to electron deficient alkynes and concomitant cyclization to N,S-heterocycles Vikas Dwivedi, ‡ Manda Rajesh, ‡ Ravi Kumar,ab Ruchir Kantc and Maddi Sridhar Reddy* (‡ equal contribution) Chem. Commun., 2017, 53, 11060-11063
3. Ag-Catalyzed Intramolecular Sequential Vicinal Diamination of Alkynes with Isocyanates: Synthesis of Fused Indole-Cyclic Urea Derivatives Manda Rajesh, Surendra Puri, Ruchir Kant and Maddi Sridhar Reddy* J. Org. Chem. 2017, 82, 10, 5169–5177 2. Synthesis of Substituted Furan/Pyrrole-3-carboxamides through a Tandem Nucleopalladation and Isocyanate Insertion Manda Rajesh, Surendra Puri, Ruchir Kant and Maddi Sridhar Reddy* Org. Lett. 2016, 18, 17, 4332–4335
1. Pd-Catalyzed Isocyanide Assisted Reductive Cyclization of 1-(2-Hydroxyphenyl)-propargyl Alcohols for 2-Alkyl/Benzyl Benzofurans and Their Useful Oxidative Derivatization Manda Rajesh, Nuligonda Thirupathi, Thota Jagadeshwar Reddy, Sanjeev Kanojiya and Maddi Sridhar Reddy* J. Org. Chem. 2015, 80, 24, 12311–12320
16. Synthesis of bridgehead-azacycles via dual C–N/C–C annulation of α-amino acids, aminals and maleimides Nagender Thadem, Manda Rajesh, Harikrishna Balaboina and Saibal Das* Org. Biomol. Chem., 2022, 20, 6368–6383
15. Activator free diastereoselective 1,3-dipolar cycloaddition: a quick access to coumarin based spiro multi heterocyclic adducts Nagender Thadem, Manda Rajesh and Saibal Das* RSC Adv., 2021, 11, 29934-29938
14. Propargylic Alcohols as Coupling Partners in Transition-Metal-Catalyzed Arene C−H Activation Gadi Ranjith Kumar, Manda Rajesh, Shuimu Lin*, Shouping Liu* Adv. Synth. Catal., 2020. 362, 5238-5256 (VIP Review article, Interanational collaboration)
13. A Sequential Activation of Alkyne and C–H Bonds for the Tandem Cyclization and Annulation of Alkynols and Maleimides through Cooperative Sc(III) and Cp*-Free Co(II) Catalysis Ravi Kumar Gurram, ‡ Manda Rajesh, ‡ Maneesh Kumar Reddy Singam, Jagadeesh Babu Nanubolu, and Maddi Sridhar Reddy* (‡ equal contribution) Org. Lett. 2020, 22, 14, 5326–5330
12. Lewis-Acid-Catalyzed Decarboxylative Annulation of 2-Aminoindole-3-Carboxylate with Ynals Involving [3 + 2] Spirocycloaddition and 2,3-Aza Migration Manda Rajesh, Ravi Kumar, Surendra Puri, Jagadeesh Babu Nanubolu and Maddi Sridhar Reddy* Org. Lett. 2020, 22, 3, 1117–1123
11. Ni-Catalyzed electrophile driven regioselective arylative cyclization of ortho-functional diaryl acetylenes for the synthesis of pyridine and indene derivatives Maneesh Kumar Reddy Singam, Attunuri Nagireddy, Manda Rajesh, Veeramalla Ganesh and Maddi Sridhar Reddy* Org. Chem. Front., 2020, 7, 30-34
10. Base Mediated Tandem Vinylogous Addition and Cyclization of γ-Phosphonyl/Sulfonyl Crotonates and Ynones: Synthesis of Functionalized 2-Pyrones Matam Parameshwar, Manda Rajesh, Sridhar Balasubramanian and Maddi Sridhar Reddy* ACS Omega 2019, 4, 20, 18846–18854
9. Rh(III)-Catalyzed Intramolecular Oxidative Annulation of Propargyl Amino Phenyl Benzamides to Access Pyrido/ Isoquinolino Quinoxalinones Gurram Ravi Kumar, Ravi Kumar, Manda Rajesh, B. Sridhar,Maddi Sridhar Reddy* Adv. Synth. Catal., 2019, 361, 4825-4830
8. Mycobacterial protein tyrosine kinase, PtkA phosphorylates PtpA at tyrosine residues and the mechanism is stalled by the novel series of inhibitors Swati Jaiswal, Aditi Chatterjee, Sapna Pandey, Kiran Lata, Ranjith Kumar Gadi, Rajesh Manda, Sanjay Kumar, Maddi Sridhar Reddy, Ravishankar Ramachandran & Kishore K. Srivastava* Journal of Drug Targeting, 2019, 27:1, 51-59
7. 3-Heterosubstituted Benzofurans from Hydroxyphenyl Propargyl Alcohols via ortho-Quinone Methide through a Metal-/Catalyst-Free Conjugate Addition/Oxy-Cyclization Manda Rajesh, Maneesh Kumar Reddy Singam, Ranjith Kumar Gadi and Maddi Sridhar Reddy* ACS Omega 2018, 3, 12, 17155–17163
6. Nickel Catalyzed syn-Selective Aryl Nickelation and Cyclization of Aldehyde/Enone-Tethered Terminal Alkynes with Arylboronic Acids Manda Rajesh, Maneesh Kumar Reddy Singam, Surendra Puri, Sridhar Balasubramanian and Maddi Sridhar Reddy* J. Org. Chem. 2018, 83, 24, 15361–15371
5. A nickel-catalyzed anti-carbometallative cyclization of alkyne–azides with organoboronic acids: synthesis of 2,3-diarylquinolines Gadi Ranjith Kumar, Ravi Kumar, Manda Rajesh and Maddi Sridhar Reddy* Chem. Commun., 2018, 54, 759-762
4. A stereoselective thiocyanate conjugate addition to electron deficient alkynes and concomitant cyclization to N,S-heterocycles Vikas Dwivedi, ‡ Manda Rajesh, ‡ Ravi Kumar,ab Ruchir Kantc and Maddi Sridhar Reddy* (‡ equal contribution) Chem. Commun., 2017, 53, 11060-11063
3. Ag-Catalyzed Intramolecular Sequential Vicinal Diamination of Alkynes with Isocyanates: Synthesis of Fused Indole-Cyclic Urea Derivatives Manda Rajesh, Surendra Puri, Ruchir Kant and Maddi Sridhar Reddy* J. Org. Chem. 2017, 82, 10, 5169–5177 2. Synthesis of Substituted Furan/Pyrrole-3-carboxamides through a Tandem Nucleopalladation and Isocyanate Insertion Manda Rajesh, Surendra Puri, Ruchir Kant and Maddi Sridhar Reddy* Org. Lett. 2016, 18, 17, 4332–4335
1. Pd-Catalyzed Isocyanide Assisted Reductive Cyclization of 1-(2-Hydroxyphenyl)-propargyl Alcohols for 2-Alkyl/Benzyl Benzofurans and Their Useful Oxidative Derivatization Manda Rajesh, Nuligonda Thirupathi, Thota Jagadeshwar Reddy, Sanjeev Kanojiya and Maddi Sridhar Reddy* J. Org. Chem. 2015, 80, 24, 12311–12320
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Contact
- West Lafayette, Indiana, United States
